徐华娥，教授、药学院药剂学系主任

疫苗研究方向 

 核酸、活细胞等仿生类疫苗及佐剂的构建和应用

联系方式

通讯：江苏省南京市江宁区龙眠大道101号至诚楼Y532，邮编211166

邮箱：xuhuae@njmu.edu.cn

简介

徐华娥，南京医科大学高层次引进人才、特聘教授、博导，南京医科大学药学院药剂学系主任，2014-2016在美国MD安德森癌症中心访学，江苏省第六期“333高层次人才培养工程”培养对象。现任中国抗癌协会纳米肿瘤学专委会委员、中国复合材料学会生物复合材料分会委员、中国药学会智能药物专业委员会青年委员、江苏省抗癌协会整合肿瘤学专委会常务委员、江苏省药学会感染药学专业委员会常务委员、江苏省药学会医院药学专委会委员、江苏省中医药学会理事会理事、南京药学会药剂与药理专委会委员等。担任国家自然科学基金优秀青年基金、面上项目及青年基金一审专家，Current Drug Delivery、Asian J Pharm Sci等杂志编委，为本领域如Adv Mater、ACS Nano, Adv Funct Mater等杂志同行评议审稿人。

课题组长期围绕多功能智能纳米递药平台的构建及在重大疾病（如肿瘤、脑部疾病、免疫性疾病等）中的应用展开相关研究，主要研究方向：1、基于肿瘤、心脑血管等重大疾病的智能药物递送体系的开发及应用；2、基因、疫苗等新型纳米药物递送体系的构建及应用；3、新型高端药物制剂的开发。作为项目负责人主持国家自然科学基金5项，以第一或通讯作者在Adv Mater、Adv Funct Mater、Adv Sci、Biomaterials、Chem Eng J 、Anal Chem等期刊上发表论文60余篇。迄今为止，根据Google Scholar统计分析，文章总被引频次超2500次，近5年被引频次1436次，H指数28。

指导学生获得如下奖项

1. 第十三届全国大学生药苑论坛创新成果二等奖；

2. 中国抗癌协会肿瘤标志物大会优秀论文奖；

3. 第二届生物磁学与磁性纳米材料学术会议暨第九届全国生物与医学纳米技术博士生学术论坛获优秀展报一等奖；

4. 第四届脑科学与药学前沿高峰论坛青年学者论文Poster比赛三等奖；

5. 南京医科大学研究生“学术之星”；

6. 南京医科大学优秀毕业生。

招生方向

1. 新型疫苗与佐剂的研发：开发新型核酸疫苗、活细胞疫苗、纳米疫苗及佐剂等；

2. 新型药物递送系统的研发：开发仿生载体、水凝胶、脂质纳米颗粒等药物递送体系，以提升药物及基因的体内靶向性和递送效率；

3. 新型生物材料的医药学应用：基于纳米技术开发新型医用生物材料。

代表性论文

1. Kaiming Li*; Xiaolin Li*; Jie Wu*; Haisi Wu*; Min Wu; Yupeng Zhou; Ya Lin; Yifan Zou; Xiqun Jiang; Huae Xu^#; A Dual Enhancing Strategy of Novel Nanovaccine Based on TIM3 Silencing Nanoadjuvants and Desialylated Cancer Cell Membrane Antigens for Personalized Vaccination Immunotherapy of Cancer, Advanced Functional Materials, 2024, 34(39): 2404956

2. Haisi Wu*; Xianbao Sun*; Kaiming Li*; Jinyu Li*; Hui Jiang*; Dan Yan; Ya Lin; Yan Ding; Yawen Lu; Xiaole Zhu; Xufeng Chen^#; Xiaolin Li^#; Gaolin Liang^#; Huae Xu^#; Pyruvate Kinase M2-Responsive Release of Paclitaxel and Indoleamine 2, 3-Dioxygenase Inhibitor for Immuno-Chemotherapy of Nonsmall Cell Lung Cancer. Advanced Science, 2025: 2409790

3. Chunming Tang*; Feng Jia*; Min Wu*; Yanling Wang; Xiaowei Lu; Jinyu Li; Yan Ding; Weilin Chen^#; Xufeng Chen^#; Feng Han^#; Huae Xu^#; Elastase-targeting biomimic nanoplatform for neurovascular remodeling by inhibiting NETosis mediated AlM2 inflammasome activation in ischemic stroke, Journal of Controlled Release, 2024, 375: 404-421

4. Ting Wu*; Tianqun Lang*; Chao Zheng; Wenlu Yan; Yu Li; Runqi Zhu; Xin Huang; Huae Xu^#; Yaping Li^#; Qi Yin^#; Promote Intratumoral Drug Release and Penetration to Counteract Docetaxel‐Induced Metastasis by Photosensitizer‐Modified Red Blood Cell Membrane‐Coated Nanoparticle, Advanced Functional Materials, 2022, 33(7): 2212109.

5. Shuo Sun*; Wei Gu*; Haisi Wu*; Qianqian Zhao*; Shiyu Qian; Hong Xiao; Kun Yang; Jian Liu; Yu Jin; Chupeng Hu; Ye Gao; Huae Xu^#; Hongyi Liu^#; Jing Ji^#; Yun Chen^#; Immunostimulant In Situ Hydrogel Improves Synergetic Radioimmunotherapy of Malignant Glioblastoma Relapse Post‐Resection, Advanced Functional Materials, 2022, 32(43): 2270246.

6. Yuqing Tong*; Wei Jiang*; Jinyu Li; Peng Teng; Lulu Wei; Huae Xu^#; Xiqun Jiang^#; Yong Hu^#; Biomimetic nanodrug breaching tumor cell membrane barrier for high-efficiency drug delivery, Chemical Engineering Journal, 2025, 514: 163206.

7. Jiajia Yin*; Chenxi Wang; Lei Zhao; Kang Xu; Yuxin Guo; Xuejiao Song^#; Jinjun Shao; Huae Xu^#; Xiaochen Dong^#; Acidity-responsive nanoplatforms aggravate tumor hypoxia via multiple pathways for amplified chemotherapy. Biomaterials. 2023, 296:122094.

8. Yatao Xu*; Ziye Wei; Wanlan Yang; Yuxin Guo; Jinjun Shao; Weili Si^#; Huae Xu^#; Wenjun Wang; Xiaochen Dong^#; H2O2 responsive CO gas release platform with CA IX-Targeting for inhibiting tumor growth and metastasis, Chemical Engineering Journal, 2023, 463: 142371.

9. Huae Xu*; Tingting Wang*; Chengbiao Yang; Xiaolin Li^#; Guan Liu; Zhimou Yang; Pankaj Kumar Singh; Sunil Krishnan^#; Dan Ding^#; Supramolecular Nanofibers of Curcumin for Highly Amplified Radiosensitization of Colorectal Cancers to Ionizing Radiation, Advanced Functional Materials, 2018, 28, 1707140.

10. Chris Y. Y. Yu*; Huae Xu*; Shenglu Ji; Ryan T. K. Kwok; Jacky W. Y. Lam; Xiaolin Li^#; Sunil Krishnan; Dan Ding^#; Ben Zhong Tang^#; Radiosensitizers: Mitochondrion-Anchoring Photosensitizer with Aggregation-Induced Emission Characteristics Synergistically Boosts the Radiosensitivity of Cancer Cells to Ionizing Radiation, Advanced Materials, 2017, 29, 1606167.